PEBC Evaluating Exam – Question set #6

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I write these articles so that these are about 10 minutes of reading time. That way, whenever you get bored with your regular study material, you can practice these questions. This is how the questions will be in your PEBC Evaluating Exam. It’s not going to be exactly the same, but it will be more or less similar.

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PEBC Evaluating Exam – Question set #6

Question 1: JT is taking Olanzapine for psychosis. He comes to the pharmacy complaining about his twisted wrist, feet pointing inwards, and tilted neck. These symptoms are indicative of dystonia. Which of the following is the drug of choice for drug-induced dystonia?

A. Benztropine
B. Propranolol
C. Trihexyphenidyl
D. Tetrabenzene
E. Verapamil

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Answer: A

Extra Pyramidal Symptoms (EPS) Mnemonic: DAPT	Treatment Mnemonic: Ben’s BAT
Dystonia – Continuous spasm + muscle contractions	Benztropine (anticholinergic)
Akathisia – Restlessness	Beta blocker (Propranolol)
Parkinson’s like Symptoms (TRAP = Tremors, Rigidity, Akinesia, Postural instability)	Anticholinergics (Beztropine, Procyclidine, Trihexyphenidyl)
Tardive dyskinesia – Irregular jerky movements – Often involves lower face + distal extremities. – May be chronic. – Can become chronic if continued for a long time.	Tetrabenzene

Image source: Active Posture

If you want to know more about dystonia, click the link above. Active Posture has written a detailed article on the topic.

Here’s the link to the article.

Note:

The above question is from antipsychotics. Mechanism of action, receptors of drugs (like 5HT1A, etc), and side effects of drugs are important.

Question 2: Which of the following statements describes the primary purpose of conducting a SWOT analysis?

A) Identification of company's vision and goals
B) Evaluation of company's year on year performance
C) Assessment of internal and external variables to plan a road map for success
D) To determine a company’s organizational structure
E) Predict sales to estimate product life cycle

Question 3: Which of the following are the side effects of Mirtazapine?

A. High Nausea and vomiting
B. High weight gain and high sedation
C. Reduces cholesterol levels
D. Uricosuric effect
E. Pitting edema

Question 4: Which of the following is not a side effect of Verapamil?

A. Bradycardia
B. Worsening of CHF
C. Constipation
D. Diarrhea
E. Myocardial vasodilation

Question 5: What is the mechanism of action of Gemfibrozil?

A. PPAR alpha agonist
B. PPAR gamma antagonist
C. PPAR alpha antagonist
D. Xanthine oxidase inhibitor
E. 5 alpha reductase II inhibitor

Question 6: What is the name of the drug for which the structure is given below

A. Furosemide
B. Metformin
C. Atorvastatin
D. Clarithromycin
E. Naproxen

Question 7: JT came to the pharmacy complaining about pain in her ear and fever. Her current symptoms are indicative of Otitis Media. Upon checking JT’s medication history, it was found that JT also experienced gout attacks in the past. Answer the following questions based on the information provided.

Question 7.1: What could be the causative agent for JT’s otitis media?

A. Treponema palladium
B. Bacillus anthracis
C. Helicobacter pylori
D. M. catarrhalis
E. Borrelia burgdorferi

Question 7.2: What is the best drug if JT did not take any antibiotics in more than a year?

A. Amoxicillin + Clavulanate
B. Azithromycin
C. Moxifloxacin
D. Clindamycin
E. Amoxicillin

Question 8: Which of the following statements about the blood clotting mechanism is correct?

A. Warfarin acts on Extrinsic pathway
B. Heparin acts on extrinsic pathway
C. Warfarin exerts its action through CNS
D. Heparin has receptor mediated action
E. aPTT is monitored for warfarin

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Answer: A

Quick revision

• Heparin acts on intrinsic pathways while Warfarin acts on extrinsic pathway

Remember the below-mentioned chart. Question is possible from this image.

Question 9: Prolong use of which of the following drugs is a risk factor for osteoporosis?

A. Prolong use of Rosuvastatin
B. Long time use of Metformin
C. extended use of Methotrexate
D. Long time use of corticosteroids
E. LABA drugs like Formoterol

Question 10: Which of the following statements are true when the data represents 99% confidence interval?

A. 99% confidence interval would be narrowe than 95% 
B. 99% confidence interval will have a positive skew
C. 99% confidence interval would be wider than 95% 
D. 99% confidence interval would have a negative skew
E.  99% confidence interval represents bimodal distribution

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Answer: C

Quick Revision

Question 11: A drug is administered orally at a dose of 100 mg and its AUC (Area Under the Curve) is found to be 50 µg·h/mL. The same drug is administered intravenously at a dose of 50 mg, and its AUC is 150 µg·h/mL. What is the absolute bioavailability of the drug?

A) 16.67%
B) 33.33%
C) 50.00%
D) 66.67%
E) 75.00%

Question 12: Which of the following stimulates the release of gastric acid in the stomach?

A. Low gastric pH
B. High duodenal pH
C. High gastric pH
D. salivary enzymes
E. low duodenal pH

Question 13: DM is a pharmacist working in a community pharmacy. He wants to check the side effects of a particular drug. Which of the following resources should DM check?

A. Cochrane database
B. Natural product database
C. CTC
D. Compendium of Pharmaceutical Speciality (CPS/RxTx)
E. CTMA

Question 14: Which of the following is not a healthcare funding source?

A. Federal government
B. Provincial government
C. Charities
D. Employee insurance
E. Mandatory public fees

Question 15: JT is a 29-year-old male who is prescribed Clomiphene to improve his sperm count. Clomiphene is a drug approved to be used for female infertility. Which of the following would best describe the use of Clomiphene in this case?

A. Adapting the prescription
B. Beneficience
C. Prioritizing patient care
D. Off label use
E. Consenting

Question 16: Which of the following drugs is not required to be taken at night time?

A. Fluvastatin
B. Lovastatin
C. Rosuvastatin
D. Pravastatin
E. Simvastatin

Question 17: What is the most common gram-positive cocci causing UTI?

A. S. saprophyticus
B. B. pertussis
C. E. coli
D. T. palladium
E. M. catarrhalis

Question 18: Which of the following is not involved in the metabolism of Acetyl Salicylic Acid?

A. Glycine conjugation
B. Glucuronidation
C. Hydrolysis
D. Glutathione conjugation
E.Hydroxylation

Question 19: What is the relationship between the 2 structures of Metformin?

A. Tautomers
B. Geometric isomers
C. Optical isomers
D. Enantiomers
E. Diastereomers

Question 20: Naltrexone is used for alcohol withdrawal. Which neurotransmitter does Naltrexone reduce in the brain?

A. Serotonin
B. Dopamine
C. Acetylcholine
D. Epinephrine
E. Norepinephrine

Question 21: Which of the following statements is not true about Medeffect?

A. Accessible to patients and care providers
B. Contains information on drug safety alerts
C. Complete details about the manufacturer or importer
D. Canada vigilance program is a part of medeffect
E. Contains information about recalls

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